Research Assistant (Clinical Genetic)

Summary:

The Molecular Otolaryngology and Renal Research Laboratories, within the Department of Otolaryngology, is seeking a Research Assistant (RA). The lab utilizes molecular and cytogenetic techniques, including PCR, Sanger sequencing, multiplex ligation-dependent probe amplification (MLPA), next-generation sequencing (NGS) and targeted genomic massively parallel sequencing for diagnostic testing of genetic hearing loss and rare complement-mediated renal disease. In this role, the RA will perform components of cytogenetic and molecular studies according to established laboratory protocols and work to maintain and improve the clinical testing environment, capabilities, and quality of data in the laboratory. This position is first shift (8am – 5pm) Monday through Friday.

Responsibilities:

  • Perform high complexity testing on clinical biological specimens such as blood, saliva, and DNA.
  • Able to properly manage time based on established priorities.
  • Perform appropriate documentation and maintain accurate and legible records.
  • Perform routine quality control, maintenance, calibration, and assist in troubleshooting of laboratory instruments.
  • Evaluate quality control results and initiate corrective action when QC metrics are not acceptable.
  • Maintain inventory and order supplies as needed.
  • Perform a variety of molecular biology procedures that may include:
  • DNA extraction
  • Processing DNA for applications including PCR and next generation sequencing (NGS)
  • Begin and ensure proper execution of analytic pipelines for both Sanger and NGS clinical tests.
  • Accept and apply feedback in a positive, constructive manner.
  • Assist in a positive and professional manner with wet-bench training for other laboratory colleagues within the section.
  • Participate in lab section meetings with others to discuss quality testing, workflow, efficiency strategies, problematic areas, and laboratory improvement.
  • Maintain effective working relationships with faculty, staff, students, and the public.
  • Ability to work with a variety of individuals and groups in a constructive and civil manner while appreciating the unique contribution of individuals from varied cultures, nationalities, genders, ages, etc.
  • Ability to utilize existing resources and learning to achieve or exceed desired outcomes of current and future organizational goals/needs. Able to demonstrate ethical behavior in a variety of situations while producing results.
  • Ability to meet or exceed customer service needs and expectations and provide excellent service in a direct or indirect manner. Ability to effectively transmit and interpret information through appropriate communication with internal and external customers.

Required Qualifications:

  • A bachelor’s degree or an equivalent combination of education and experience. Preference: Microbiology, Biology, Genetics or Similar
  • Over 2 years’ experience with project coordination including time management, decision making, and self-direction in microbiology, biology, chemistry, or a similar discipline.
  • Excellent organizational, interpersonal, and communication (both verbal and written) skills.
  • Experience preparing solutions and purchasing supplies.
  • Demonstrated experience with DNA quantification using established protocol including spectrophotometer and fluorometric methods .
  • Willingness to learn relevant lab protocols under supervision of the principal investigator and other staff.
  • Proficiency in computer software applications, including Microsoft Office Suite and LIMS.
  • Ability to analyze information and situations, prioritize tasks, and develop solutions to challenges.
  • Ability to use good judgment while working independently and in a team setting.
  • Experience in general laboratory upkeep such as sample inventory, biohazard waste management, and autoclave use.

Postdoctoral Fellow

A postdoctoral position is immediately available in the Molecular Otolaryngology and Renal Research Laboratories (MORL) at the University of Iowa.  The MORL research program in hearing research is focused on deciphering the genetic mechanisms underlying hearing disorders and developing new therapies for hearing loss.

We employ a multidisciplinary approach that includes next-generation-sequencing technologies (whole exome sequencing, RNA-seq and ChIP-seq), transgenic and knockout mice, cell culture, immunohistochemistry, electrophysiology, molecular and biochemical assays and micro-RNA-based gene therapy. 

Applicants must have a Ph.D. degree, experience in molecular biology and genetics, and a committed desire to learn and apply cutting-edge technologies to hearing research.  Special attention will be given to applicants with experience in mice models for deafness and/or gene therapy.  Preferred candidates are highly motivated, independent, with excellent organizational, written and oral communication skills.  The candidate will join an exciting research environment with state-of-the-art facilities.  The position offers exceptional training in the genetics of neurosensory disorders and molecular therapeutics.

Please send a CV, including a summary of research experience and interests, as well as contact information for three references to Richard Smith, MD (richard-smith@uiowa.edu).

 

Research Associate

Functional Team

* This position is not eligible for university sponsorship for employment authorization *

BASIC FUNCTION

University of Iowa Health Care Department of Otolaryngology is seeking a Research Associate to perform clinical functional testing in the area of complement-mediated rare renal disease. The Research Associate will support clinical and research efforts while contributing to the overall success of the functional team in the Molecular Otolaryngology and Renal Research Laboratories – Clinical Diagnostics Services (MORL CDS). This advanced-level position involves conducting experiments, managing data, and assisting in the development of hypotheses and protocols, with opportunities for professional growth. The key areas of responsibilities include conducting clinical and research activities/experiments, collecting, analyzing, and summarizing data, preparing reports, contributing to manuscripts/publications, administrative and project management, facilities and equipment management, and supervision/staffing.

DUTIES TO INCLUDE:

Clinical Diagnostic Service:

  • Execute clinical laboratory activities following established protocols and guidelines. Conduct laboratory assays, including enzyme-linked immunosorbent assay (ELISA), turbidimetric assays, and immunofixation electrophoresis (IFE).
  • Maintain, organize, and report data using MS Word, Excel, and other relevant software, ensuring accuracy and consistency.
  • Coordinate daily activities with team members to meet daily, weekly, and monthly deadlines, ensuring timely achievement of clinical service.
  • Perform and meet proficiency and competency testing standards while maintaining meticulous records in compliance with regulatory requirements.

The department intends to hire for one position as either a Research Assistant, requisition 26002127 or Research Associate, requisition 26002128, based on the qualifications of the successful candidate. Please apply to the specific position for which you which to be considered or both.

REQUIRED QUALIFICATIONS:

  • Bachelor’s degree in a relevant field (e.g., biology, biochemistry, immunology) or equivalent combination of education and experience.
  • 3–5 years of hands-on wet-lab experience in a biology/immunology laboratory, with ability to work independently.
  • Proficiency in common lab techniques such as tissue culture, PCR, ELISA, Western blotting/protein electrophoresis, and functional complement/hemolytic assays (as applicable).
  • Demonstrated ability to troubleshoot assays, maintain accurate lab records, and manage multiple priorities.
  • Strong organizational and time management skills with exceptional attention to detail.
  • Ability to work collaboratively in a team-oriented environment.
  • Proficiency with common software tools (Microsoft Office); experience with data management and analysis tools (e.g., FileMaker Pro and/or R).

  • Excellent written and oral communication skills.

     

DESIRED QUALIFICATIONS:

  • Experience working in a CLIA-certified and/or other regulated laboratory environment.
  • Familiarity with regulatory compliance, SOP-driven workflows, quality assurance/quality control, and documentation standards.

Additional Information

  • Classification Title: Research Associate
  • Appointment Type: Professional and Scientific
  • Schedule: Full-time
Compensation
  • Pay Level: 4A
Contact Information

Research Assistant

Functional Team

* This position is not eligible for university sponsorship for employment authorization. *

BASIC FUNCTION

Perform research in the area of complement mediated renal diseases, perform clinical testing as a member of the CDS renal team and perform research and development.  The Research Assistant will work with frozen serum and plasma samples received into the Molecular Otolaryngology and Renal Research Laboratories – Clinical Diagnostics Services (MORL CDS) for Functional and Biomarker testing.  The RA will perform sample accessioning, aliquoting, perform assays, report results, maintain inventory and quality management for the CDS.

The department intends to hire for one position as either a Research Assistant, requisition 26002127 or Research Associate, requisition 26002128, based on the qualifications of the successful candidate. Please apply to the specific position for which you which to be considered or both.

REQUIRED QUALIFICATIONS

  • Bachelor’s degree in a relevant field (e.g., biology, biochemistry, immunology) or an equivalent combination of education and experience.

  • Excellent written and verbal communication skills.

  • Hands-on wet-lab experience with immunology/biochemistry techniques, including PCR and/or ELISA and/or DNA/protein electrophoresis.

  • Strong attention to detail with accurate documentation and data recording.

DESIRED QUALIFICATIONS

  • Experience handling human specimens (serum/plasma) and following biosafety practices.

  • Familiarity with complement assays or related immunoassays.

  • Experience working with SOPs and basic quality practices.

 

Additional Information
  • Classification Title: Research Assistant
  • Appointment Type: Professional and Scientific
  • Schedule: Full-time
Compensation
  • Pay Level: 3A
Contact Information

Graduate Student Program

Graduate students can enter the MORL through the Biosciences Program, the Interdepartmental Genetics PhD Program, the Medical Scientist Training Program or the Molecular Physiology and Biophysics Program.

Summer Research Opportunities

Summer research opportunities are available for medical students and undergraduates. If interested, contact Richard Smith, MD (richard-smith@uiowa.edu).

Preliminary enquiries, together with a CV, should be sent to: morl@uiowa.edu

About the Department of Otolaryngology

The department of Otolaryngology was founded in 1922, the department is one of the oldest in the United States and one of the most comprehensive in the world. Our department prides itself on its highest standards of patient care. For this we credit the balance that we strike between clinical work, training, and research. Each of these elements contributes to a thorough and compassionate approach to patient care.

Equal opportunity/affirmative action employer

The University of Iowa is an equal opportunity/affirmative action employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, religion, national origin, age, sex, pregnancy (including childbirth and related conditions), disability, genetic information, status as a U.S. veteran, service in the U.S. military, sexual orientation, gender identity, or associational preferences.

Persons with disabilities who need assistance or accommodations with the application or interview process may contact University Human Resources/Faculty and Staff Disability Services, (319) 335-2660 or fsds@uiowa.edu.  For jobs in UI Health care, please contact UI Health care Leave & Disability Administration at 319-356-7543.