Tests Included
The panel includes 18 tests:
- Complement levels (C3, C4, factor B, factor D, C5, Properdin, factor H, and factor I)
- Complement activation products (C3c, Ba, Bb, and Soluble C5b-9)
- Pathway activity assays such as CH50, APFA, C3b Deposition Assay and a fluid-phase activity assay
- Detection of autoantibodies (Factor H autoantibodies and FB autoantibodies)
MORL Screening Methodology
Functional assays, enzyme-linked immunosorbent assays (ELISA), turbidimetric assays and immunofixation electrophoresis (IFE) are utilized to assess the functionality and integrity of the complement system in patients with atypical Hemolytic Uremic Syndrome / complement-mediated Thrombotic Microangiopathy.
- Serum and EDTA plasma samples must be frozen to below -80°C immediately after separation from cells and shipped on dry ice. These samples remain viable for at least six months when stored at -80°C.
- All serum and EDTA plasma samples MUST be processed and frozen down to -80°C immediately after collection
- Labeled with the sample type AND patient’s name, DOB, MRN and sex
- Sample type must be clearly labeled (either serum or EDTA plasma)
- Cryovials should be put in zip lock bags and completely covered in dry ice to keep the sample frozen until it arrives in the lab
- Shipped overnight on at least 5 lbs of dry ice
- Shipping and receiving dock closed on weekends and holidays
- Deliveries accepted Monday - Friday
If samples arrive thawed they will be REJECTED.
Quick Facts
- CPT codes: 83516 (x2), 83520, 86160 (x11), 86161 (x2), 86162, 86334
- Test code: aHUS-FP
- Turnaround time: 4 weeks
- Cost: $4037.40
*This cost represents a 10% discount over ordering each test in the panel a la carte.
The Clinical Diagnostics Service of the Molecular Otolaryngology & Renal Research Laboratories is a CLIA-approved, Joint Commission-accredited diagnostic laboratory.