MORL Screening Methodology
Immunofixation electrophoresis (IFE) integrates electrophoresis with immunofixation to identify C3 degradation products, providing an indirect assessment of dysregulation of C3 convertase. The quantification of the conversion of C3 to C3-activation products is performed.
Sample Requirements
- 1ml frozen serum
Sample Stability
- Serum samples must be frozen to below -80°C immediately after separation from cells and shipped on dry ice. These samples remain viable for at least six months when stored at -80°C.
Shipping Requirements
- All serum samples MUST be processed and frozen down to -80°C immediately after collection
- Labeled with the sample type AND patient’s name, DOB, MRN and sex
- Cryovials should be put in zip lock bags and completely covered in dry ice to keep the sample frozen until it arrives in the lab
- Shipped overnight on at least 5 lbs of dry ice
- Shipping and receiving dock closed on weekends and holidays
- Deliveries accepted Monday - Friday
If samples arrive thawed they will be REJECTED.
Indications for Testing
Immunofixation electrophoresis (IFE) integrates electrophoresis with immunofixation to identify C3 degradation products, providing an indirect assessment of dysregulation of C3 convertase. The quantification of the conversion of C3 to C3-activation products is performed.
The Clinical Diagnostics Service of the Molecular Otolaryngology & Renal Research Laboratories is a CLIA-approved, Joint Commission-accredited diagnostic laboratory.