Complete List of Genetic Renal Panel Familial Genes

Single nucleotide variants in a gene currently testing in the Genetic Renal Panel or copy number variants in the CFH-CFHR5 region. If a proband was tested outside of the MORL, please contact our administration team at morl@uiowa.edufor sample and requisition instructions. 

MORL Screening Methodology

PCR and Sanger sequencing using custom DNA oligos.

Shipping Requirements

(SEND ONLY ONE OF THE FOLLOWING SAMPLE TYPES) : 

  • 5µg DNA suspended in ≥ 50µl elution buffer
    • minimum concentration 50ng/µl
    • A260/A280 1.8-2.0
  • 3-5 cc EDTA Whole Blood
    • room temperature
  • Saliva
    • DNA Genotek, ORAGene Discover, OGR-500
  • Buccal Swabs 
    • at least 4 swabs

    • DNA Genotek, OraCollect, OCD-100

       

Click here to print sample and shipping requirements.

  • Whole Blood Sample Stability for DNA extraction
    • EDTA Whole Blood is stable for 7 days at room temperature and 4 months in the refrigerator
  • Saliva Collection Kits and Buccal Swabs Sample Stability
    • Per the manufacturer for samples collected following the instructions provided with kit/swabs: OGR-500 saliva collection kits are stable at room temperature for several years and OCD-100 buccal swabs stable up to 80 days.  Both of these kits can be shipped at room temperature.

  • Labeled with the sample type AND patient’s name, DOB, MRN and sex
  • Room temperature (DO NOT FREEZE)
  • Samples may be refrigerated if delivery is delayed
  • Shipping and receiving dock closed on weekends and holidays 
    • Deliveries accepted Monday - Friday 

Click here to print sample and shipping requirements.

Information

Quick Facts

  • CPT codes: 81403
  • Test code: GRPFAM
  • Turnaround time: 2 weeks 
  • Cost: $220
Requisition Form

To order:

Use this requisition form to order this test.

Background Information

The Genetic Renal Panel is comprehensive, personalized and efficient, and can provide information on best methods of treatment, prognosis and recurrence chance for patients diagnosed with complement-mediated TMAs and C3G including (Fengxiao Bu et. al, J Am Soc Nephrol 27: 1245 – 1253, 2016. doi:10.1681/ASN.2015040385): 

  • Complement-mediated Hemolytic Uremic Syndrome (aHUS)
  • Upshaw-Schulman syndrome (a hereditary form of Thrombotic Thrombocytopenic Purpura (TTP))
  • Methylmalonic aciduria (cobalamin deficiency) cblC type with homocystinuria
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency,
  • Denys-Drash syndrome (DDS)
  • Dense Deposit Disease (DDD) 
  • C3 Glomerulonephritis (C3GN)

 

Family members wishing to be tested for a single nucleotide variant in a gene currently included in the Genetic Renal Panel or a copy-number variant in the CFH-CFHR5 genomic region can order Genetic Renal Panel Familial testing to provide insight to penetrance of disease, risk of disease development, and variant interpretation when coupled with biomarker testing. 

Genetic Renal Panel has a diagnostic sensitivity and specificity that is greater than 99%

Genetic testing for renal disease answers many important questions pertaining to patient care. The Genetic Renal Panel provides information on recurrence chance, prognosis, and best methods of treatment.

The Clinical Diagnostics Service of the Molecular Otolaryngology & Renal Research Laboratories is a CLIA-approved, Joint Commission-accredited diagnostic laboratory.