Complete List of Genetic Renal Panel Genes

  • CFH, CFI, MCP (CD46), CFB, CFHR5, C3, THBD, DGKE, PLG, ADAMTS13, MMACHC, G6PD and WT1 
  • Two single nucleotide variants that could compromise responsiveness to Eculizumab, C5: c.2653C>T, p.Arg885Cys and c.2654G>A, p.Arg885His  
  • Copy number variation screening of the CFH-CFHR5 genomic region using multiplex ligation-dependent probe amplification (MLPA)

MORL Screening Methodology

An up-to-date custom targeted genomic enrichment and massively parallel sequencing panel coupled with multiplex ligation-dependent probe amplification (MLPA) makeup the Genetic Renal Panel test.

(SEND ONLY ONE OF THE FOLLOWING SAMPLE TYPES) : 

  • 5µg DNA suspended in ≥ 50µl elution buffer
    • minimum concentration 50ng/µl
    • A260/A280 1.8-2.0
  • 3-5 cc EDTA Whole Blood
    • room temperature
  • Saliva
    • DNA Genotek, ORAGene Discover, OGR-500
  • Buccal Swabs 
    • at least 4 swabs

    • DNA Genotek, OraCollect, OCD-100

       

Click here to print sample and shipping requirements.

  • Whole Blood Sample Stability for DNA extraction
    • EDTA Whole Blood is stable for 7 days at room temperature and 4 months in the refrigerator
  • Saliva Collection Kits and Buccal Swabs Sample Stability
    • Per the manufacturer for samples collected following the instructions provided with kit/swabs: OGR-500 saliva collection kits are stable at room temperature for several years and OCD-100 buccal swabs stable up to 80 days.  Both of these kits can be shipped at room temperature.

  • Labeled with the sample type AND patient’s name, DOB, MRN and sex
  • Room temperature (DO NOT FREEZE)
  • Samples may be refrigerated if delivery is delayed
  • Shipping and receiving dock closed on weekends and holidays 
    • Deliveries accepted Monday - Friday 

Click here to print sample and shipping requirements.

Information

Quick Facts

  • CPT codes: 81479, 81405
  • Test code: GRP08
  • Turnaround time: 3 weeks
  • Cost: $3000
Requisition Form

To order:

Use this requisition form to order this test.

Background Information

The Genetic Renal Panel is comprehensive, personalized and efficient, and can provide information on best methods of treatment, prognosis and recurrence chance for patients diagnosed with complement-mediated TMAs and C3G including (Fengxiao Bu et. al, J Am Soc Nephrol 27: 1245 – 1253, 2016. doi:10.1681/ASN.2015040385): 

  • Complement-mediated Hemolytic Uremic Syndrome (aHUS)
  • Upshaw-Schulman syndrome (a hereditary form of Thrombotic Thrombocytopenic Purpura (TTP))
  • Methylmalonic aciduria (cobalamin deficiency) cblC type with homocystinuria
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency,
  • Denys-Drash syndrome (DDS)
  • Dense Deposit Disease (DDD) 

 

Genetic Renal Panel has a diagnostic sensitivity and specificity that is greater than 99%

Genetic testing for renal disease answers many important questions pertaining to patient care. The Genetic Renal Panel provides information on recurrence chance, prognosis, and best methods of treatment.

The Clinical Diagnostics Service of the Molecular Otolaryngology & Renal Research Laboratories is a CLIA-approved, Joint Commission-accredited diagnostic laboratory.