Genes Included in Genetic Renal Panel v8

  • CFH (Complement Factor H)
  • CFI (Complement Factor I)
  • MCP (Membrane Co-Factor Protein or CD46)
  • CFB (Complement Factor B)
  • CFHR5 (Complement Factor H Related 5)
  • THBD (Thrombomodulin)
  • C3 (Complement Component 3)
  • ADAMTS13 (A Disintegrin and Metalloproteinase with a Thrombospondin Type 1 Motif, Member 13)
  • PLG (Plasminogen)
  • DGKE (Diacylglycerol Kinase, Epsilon)
  • MMACHC (Metabolism of Cobalamin Associated C)
  • G6PD (Glucose-6-Phosphate Dehydrogenase)
  • WT1 (WT1 Transcription Factor)
  • C5 (c.2653C>T, p.Arg885Cys and c.2654G>A, p.Arg885His) - two single nucleotide variants that could compromise responsiveness to Eculizumab

Multiplex ligation-dependent probe amplification (MLPA) is included in the testing to determine copy number variants over the CFH-CFHR5 genomic region.

Cost & CPT Codes

The Clinical Diagnostics Service of the Molecular Otolaryngology & Renal Research Laboratories is a CLIA-approved, Joint Commission-accredited diagnostic laboratory.